The song is, obviously, an ode to weed, with all three rappers spending the song's 3 minutes and 41 seconds espousing their love for smoking. The hook of the song features an uncredited woman asking the titular drug dealer what he's got to offer her.
Over plucky keys, Santana explains, "I'm a certified pothead/ So you don't ever gotta ask why my eyes red." It's probably safe to assume that the rapper had a good 4/20.
Listen to "Mr. Weedman" above.